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          CDAP 活化多糖制備5 型肺炎鏈球菌莢膜多糖-破傷風類毒素結合疫苗

          【摘要】目的用 1-氰基-4-二甲氨基-吡啶四氟硼酸( CDAP)代替溴化氰( CNBr)活化 5型肺炎鏈球菌莢膜多糖,制備 5型肺炎鏈球菌莢膜多糖-破傷風類毒素( TT)結合疫苗。方法將 5型肺炎鏈球菌莢膜多糖溶液加 CDAP活化,經 ADH和縮合劑 EDAC與破傷風類毒素進行偶聯,經凝膠過濾柱層析純化,得到 5型肺炎鏈球菌多糖-TT結合物,并對其生化指標、血清學特異性、安全性及免疫原性進行檢測。結果多糖-TT結合物的游離多糖含量與多糖的衍化率成反比;血清學特異性良好;經動物實驗證明其安全性合格;具有良好的免疫原性,且游離多糖含量越低,免疫原性越強。結論用 CDAP活化工藝制備的 5型肺炎鏈球菌莢膜多糖-TT結合物適宜制備疫苗。
            【關鍵詞】 CDAP;肺炎鏈球菌;莢膜多糖;破傷風類毒素;結合疫苗

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