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          圓環疫苗分類和各類優缺點

                 現階段我國市場圓環苗主要為兩種種商品化疫苗:全病毒滅活苗,亞單位疫苗。全病毒滅活疫苗是先對病毒培養,然后用加熱或化學劑將其滅活制備而成的疫苗;亞單位疫苗是利用DNA重組技術,將編碼病原微生物保護性抗原的基因導入原核或真核細胞,使其在受體細胞中高效表達,分泌保護性抗原蛋白。 
                  圓環全病毒滅活苗特點
                  1.全病毒滅活苗常用佐劑分為水包油型(O/W)、油包水型(W/O),圓環病毒滅活疫苗因其抗原分子小、免疫原性不強,不能引起足夠強的免疫應答,需要佐劑輔助刺激機體才能產生較強的免疫應答,油佐劑加入疫苗制劑后能促進、增強或延長機體對抗原特異性免疫應答,但油佐劑常常會引起豬群過敏反應大大降低免疫應答的效果。
                   2.因圓環病毒不易滅活,圓環病毒全病毒滅活疫苗存在滅活不徹底的隱患。
                   3.圓環病毒不易培養在國際上應用PK-15傳代細胞培養PCV2的最高含量很難超過103.5TCID50/mL,抗原含量無法保證。 
                   圓環病毒亞單位疫苗的特點
                   1.水性佐劑,無副反應,抗體產生迅速。
                   2.疫苗本質就是蛋白,而不是活的圓環病毒,安全有效消除了滅活不徹底的隱患。 
                   3.亞單位疫苗提取的是中和蛋白,有效抗體產生的量更高。
                   4.亞單位疫苗中添加免疫增強劑更有效地提高了細胞免疫和體液免疫,為豬群健康奠定了更堅實的基礎。

           

          凤凰彩票

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