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          通用癌癥疫苗研究邁出重要一步

                  德國一個研究小組利用免疫系統對病毒感染的反應開發出一種納米粒子RNA疫苗,并在實驗鼠和3位晚期黑色素瘤患者身上成功誘發了抗癌免疫反應。該研究為通用癌癥疫苗的出現鋪平了道路,有望讓癌癥免疫療法成為現實。
                  這項發表在最新一期《自然》雜志上的研究,介紹了一種通過調整機體免疫反應來對抗癌癥的方法。其核心是一種由RNA-脂質復合物組成的疫苗。這種疫苗通過靜脈注射進入體內,目標是一種被稱為樹突狀細胞的免疫系統細胞。
                  德國美茵茨大學的尤格•薩赫和他的研究團隊發現,通過調整納米微粒的電荷,讓這些RNA攜帶輕微的負電荷就足以讓它們針對樹突狀細胞。RNA-脂質復合物能把RNA用脂類膜完全包裹起來,以保護其不被身體降解。與此同時,這種脂質物質還能把RNA藥物導向需要去的地方,幫助它們被樹突狀細胞、脾臟、淋巴結和骨髓中的巨噬細胞吸收,之后這些RNA會被翻譯成癌癥特異性的抗原。
                  實驗結果顯示,這種疫苗在多個小鼠腫瘤模型中可以誘發一個強烈的抗原特異性T細胞應答,并產生一個強力的α型干擾素對癌癥的發展產生排斥反應。該結果在人類臨床實驗中也得到了證實。該疫苗第一期臨床劑量遞增試驗的初步結果顯示,3個黑色素瘤患者接受了低劑量疫苗后,表現出了強有力的α型干擾素和抗原特異性T細胞應答。
                  研究人員稱,由于幾乎所有基于蛋白的抗原都可以通過RNA進行編碼,這種納米疫苗具備成為通用癌癥疫苗的潛力。這項研究意味著,通用癌癥疫苗研究終于邁出關鍵一步。(生物谷Bioon.com)
           

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